Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hif1a  hypoxia inducible factor 1, alpha subunit   (Synonyms: bHLHe78, HIF1alpha, HIF-1alpha, MOP1)
Results	Reference
1	J:105998 Galabova-Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen AP, Silva A, Baccarini M, Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
1	J:243840 Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B, Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511
1	J:122656 Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K, Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25;282(21):15578-88
1	J:170943 Holscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A, Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
1	J:68468 Huss WJ, Hanrahan CF, Barrios RJ, Simons JW, Greenberg NM, Angiogenesis and prostate cancer: identification of a molecular progression switch. Cancer Res. 2001 Mar 15;61(6):2736-43
1	J:339746 Jin R, Zhang H, Lin C, Guo J, Zou W, Chen Z, Liu H, Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis. Exp Mol Med. 2023 Jan;55(1):69-80
1	J:137276 Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R, Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008 Jun 19;453(7198):1117-21
1	J:211963 Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S, Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):134-44
1	J:320427 Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH, Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec;92(6):1370-1383
1	J:137720 Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T, Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest. 2008 Jul;118(7):2393-403
1	J:160163 Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H, von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010 May;137(9):1563-71
1	J:207483 Li Y, Hao H, Tzatzalos E, Lin RK, Doh S, Liu LF, Lyu YL, Cai L, Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biol Open. 2014;3(2):172-84
1	J:214967 Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E, Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 1;393(1):124-36
1	J:113127 Matsui T, Kanai-Azuma M, Hara K, Matoba S, Hiramatsu R, Kawakami H, Kurohmaru M, Koopman P, Kanai Y, Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006 Sep 1;119(Pt 17):3513-26
1	J:240073 Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T, Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-beta signalling. Nat Commun. 2016 Jun 22;7:12047
1	J:120969 Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP, Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell. 2007 Apr;11(4):311-9
1	J:208938 Reinert RB, Brissova M, Shostak A, Pan FC, Poffenberger G, Cai Q, Hundemer GL, Kantz J, Thompson CS, Dai C, McGuinness OP, Powers AC, Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes. 2013 Dec;62(12):4154-64
1	J:186587 Rennie MY, Detmar J, Whiteley KJ, Jurisicova A, Adamson SL, Sled JG, Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice. Am J Physiol Heart Circ Physiol. 2012 Mar 15;302(6):H1261-73
1	J:160375 Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS, VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol. 2010 May;176(5):2269-82
1	J:253433 Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC, Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle. PLoS One. 2016;11(5):e0154309
1	J:232285 Tibboel J, Groenman FA, Selvaratnam J, Wang J, Tseu I, Huang Z, Caniggia I, Luo D, van Tuyl M, Ackerley C, de Jongste JC, Tibboel D, Post M, Hypoxia-inducible factor-1 stimulates postnatal lung development but does not prevent O2-induced alveolar injury. Am J Respir Cell Mol Biol. 2015 Apr;52(4):448-58
1	J:180153 Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, Hastie N, Vainio S, Elenius K, ErbB4 Modulates Tubular Cell Polarity and Lumen Diameter during Kidney Development. J Am Soc Nephrol. 2012 Jan;23(1):112-22
1*	J:101671 Wagner KF, Hellberg AK, Balenger S, Depping R, Dodd-O J, Johns RA, Li D, Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alpha. Am J Respir Cell Mol Biol. 2004 Sep;31(3):276-82
1*	J:154906 Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X, Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development. 2009 Dec;136(24):4143-53
1	J:243365 Williams CJ, Chu A, Jefferson WN, Casero D, Sudhakar D, Khurana N, Hogue CP, Aryasomayajula C, Patel P, Sullivan P, Padilla-Banks E, Mohandessi S, Janzen C, Wadehra M, Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. J Pathol. 2017 Jun;242(2):246-259
1	J:228857 Zhu X, Wang F, Zhao Y, Yang P, Chen J, Sun H, Liu L, Li W, Pan L, Guo Y, Kou Z, Zhang Y, Zhou C, He J, Zhang X, Li J, Han W, Li J, Liu G, Gao S, Yang Z, A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014 Oct;10(10):e1004589